They possess properties that are not only wellsuited to the needs of pharmaceutical applications, but that enable construction of drug delivery systems that address critical patient needs. The effects of several plasticizers on the following properties of cellulose acetate phthalate films were studied. It may also be used as a matrix material in solid dose forms. Cellulose acetate phthalate european pharmacopoeia ep. Cellulose acetate phthalate cap is a pharmaceutical excipient which has been used for over four decades for enteric film coating of tablets and capsules. A further version, cellulose acetate phthalate where the compound has been reacted with phthalic acid, is often used to form the film coatings that protect medicines in tablet form and prevent any interaction with the gullet before the tablet reaches the intestines. Safety data sheet eastmantm cellulose acetate butyrate cab 5530. Phma7889 cellulose ester blends for tunable drug delivery. Polyethersulfone pescellulose acetate phthalate cap. Electrospun cellulose acetate phthalate fibers for semen. The properties of enteric tablet coatings made from polyvinyl acetate phthalate and cellulose acetate phthalate proceedings. Cellulose acetate phthalate is produced by a reaction between the partial acetate ester of cellulose and phthalic anhydride in the presence of a tertiary organic base such as pyridine, or a strong acid such as sulfuric acid. The substance identifiers displayed in the infocard are the best available substance name, ec number, cas number andor the molecular and structural formulas.
Cellulose acetate phthalate, hypromellose phthalate. Cellulose acetate phthalate cap, also known as cellacefate and cellulosi acetas phthalas, is a commonly used polymer phthalate in the formulation of pharmaceuticals, such as the enteric coating of tablets or capsules and for controlled release formulations. Recent studies indicate that cellulose acetate phthalate cap, an inactive pharmaceutical excipient commonly used in the production of enteric tablets and capsules, is a broad specificity microbicide against diverse sexually transmitted pathogens. Stage 6 harmonization official august 1, 2017 cellulose 1 w weight of cellulose acetate taken, calculated cellulose acetate on the dried basis g acceptance criteria. Drug release from tablets containing cellulose acetate.
Cellulose acetate phthalate cap manufacturers, suppliers. Cellulose acetate an overview sciencedirect topics. Drug release from tablets or tabletted microcapsules was measured in a disintegration apparatus and an in vitro variableph release simulator of the flow type. Pdf diclofenac sodium ds microspheres were prepared with two different polymers, ethyl cellulose ec and cellulose acetate phthalate. Release kinetic studies of aspirin microcapsules from. The term acetate is often used to refer to any plastic film.
Cellulose acetate blends effect of plasticizers on properties and biodegradability. Thats because acetate film has been around since before world war i. Effect of cellulose acetate phthalate and polyethylene glycol on physical properties and release of theophylline from microcapsules 29 measurement of flowability the angle of repose was measured using funnel with fixedbase cone. It is a hygroscopic white to offwhite freeflowing p. Cellulose acetate phthalate or cellacefate, nf cellulose esters are part of a large family of cellulose derivatives that have a long history of use in pharmaceutical applications.
Eastman cap cellulose acetate phthalate, nf enteric coating material is a phsensitive cellulose derivative designed for coating pharmaceutical tablets, capsules or granules. Cellulose acetate phthalate cap was employed as a phdependent polymeric material. Cn105504359a cellulose acetate particles and preparing. Details of the supplier of the safety data sheet manufacturer supplier eastman chemical company 200 south wilcox drive. Cap, hpmcp and pvap, are polymers modified by esterification with orthophthalic acid groups. In the pharmaceutical industry, hypromellose phthalate is used as a coating agent for tablets and granules. These properties include very low toxicity, endogenous andor dietary decomposition products, stability, high. Cellulose acetate phthalate as an enteric coating material malm. A wide variety of cellulose acetate powder options are available to you, there are 471 suppliers who sells cellulose acetate powder on, mainly located in asia. Cellulose acetate phthalate cap is one of the potential hydrophilic organic polymers that can be used and explored in psf polymer blend technique to improve hydrophilicity and performance of psf membranes. Us5888550a cellulose acetate phthalate enteric coating. This process proceeds stepwise until all the acetate groups are released. Huang c, soenen s, van gulck e, vanham g, rejman j, van calenbergh s, et al. Hypromellose phthalate occurs as white to slightly offwhite, freeflowing flakes or as a granular powder.
But it readily dissolves in slight alkaline medium of small intestine. The substance identity section is calculated from substance identification information from all echa databases. Guideline on the use of phthalates as excipients in human medicinal. However, it was only after the year 2000 that a description of the material for soft capsules appeared, with gelatin being used in a mixture with wellknown acidinsoluble polymers such as methacrylic acid copolymers, hypromellose phthalate, hypromellose acetate succinate, cellulose acetate phthalate, etc. They considered the cellulose acetate as the basic polymer. Sep 25, 2001 cellulose acetate phthalate cap, a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 hiv1 and several herpesviruses. Pdf characterization of cellulose acetate phthalate cap.
Guideline on the use of phthalates as excipients in human. Cellulose acetate is used as a film base in photography, as a component in some coatings, and as a frame material for eyeglasses. Enhanced bioavailability and anticancer effect of curcuminloaded electrospun nanofiber. Cap powder has been studied by various methods to determine characteristics that have an influence on its functionality. Phthalate polymers with no known toxicityhypromellose phthalate hmp, cellulose acetate phthalate cap, and polyvinyl acetate phthalate pvapwere included in 75 rx products. According to the preparing method for the cellulose acetate particles, products having the advantages of being crystal clear in color, moderate in hardness, free of yellowing and few in pit and facilitating followup. Here is the listings of cellulose acetate phthalate cas 9004380, cellulose acetate phthalate manufacturers, suppliers and exporters. Provided are enteric coating compositions which utilize a low viscosity cellulose acetate phthalate polymer as a film former. Cellulose acetate phthalate an overview sciencedirect. It is a cellulose polymer where about half of the hydroxyls are esterified with acetyls, a quarter are esterified with one or two carboxyls of a phthalic acid.
Cellulose acetate phthalate is used as an enteric coating on capsules or tablets so they dont dissolve until they reach the small intestine. General properties include transparency, glossiness, natural feel and good toughness. Apr 05, 2019 hypromellose phthalate hydroxypropyl methylcellulose phthalate, or hpmcp is a phthalic acid ester of hydroxypropyl methylcellulose. Cellulose acetate is the acetate ester of cellulose. Cellulose acetate phthalate, also known as cellacefate and cellulosi acetas phthalas, is a commonly used polymer phthalate in the formulation of pharmaceuticals, such as the enteric coating of tablets or capsules and for controlled release formulations. Expired fee related application number ep19980956122 other languages. Enteric coatings are selectively insoluble substances they wont dissolve in the acidic juices of the stomach, but they will dissolve in the higher ph above ph 5. Cellulose acetate sheet manufacturers, wholesale cellulose. Cellulose acetate phthalate is commonly applied to soliddosage forms either by coating from organic or aqueous solvent systems or by direct compression. These shown cellulose acetate phthalate manufacturing companies are known for its product quality. Effect of plasticizers on some physical properties of cellulose acetate. The effect of concentration and type of plasticizer on the. It is widely used for textiles, cigarette filters etc.
Cellulose acetate butyrate cab is a mixed ester of cellulose. Cellulose acetate phthalate is soluble in buffer solutions at ph values as low as 6. Cap is a commercial ester ob tained from modification of cellulose and it can be used to synthesis of network chains, as described in this work. Thereafter, we began to manufacture acetate tow by the implementation of spinning technology.
Cellulose acetate polymer is chemically degraded by a process called hydrolysis, which means breaking apart by the addition of water 9. While some of the parameters are well known, such as freeacid content and substituent composition, new methods have been developed to examine them. Cellulose acetate phthalate definition of cellulose acetate. Micronized cap, available commercially as aquateric and containing additional ingredients required for micronization, used for tablet coating from water dispersions, was shown to adsorb and inactivate the human immunodeficiency virus hiv1. Preparation, characterization, and in vitro diffusion. It is inexpensive and generally regarded as a nontoxic material free of adverse effects.
Enteric polymers used to coat oral pharmaceuticals consist of various substances, such as cellulose acetate phthalate cap, polyvinyl acetate phthalate pvap. Eastman cellulose ester nomenclature eastman cellulose acetates such as ca39810 nfep and ca320s nfep and hydrophobic cellulose acetate butyrate cab17115 nf provide films with a wide range of waterapi permeabilities. Depending on the way it has been processed cellulose acetate can be used for great. Three otc drug and dietary supplement products listed dbp, 64 listed dep, and 90 indicated inclusion of polymers. Abstract cellulose acetate phthalate is soluble in buffer solutions at ph values as low as 6. However, the invitro release characteristics of drug from the microcapsules are subject to confirmation in animal and human studies for concluding enhanced bioavailability and reduced dose frequency for improved patient compliance. Cap has been used for enteric film coating of tablets and capsules. Soft gelatin films modified with cellulose acetate. The invention belongs to the field of highmolecular material production and processing and particularly relates to cellulose acetate particles and a preparing method thereof. Electrospun cellulose acetate phthalate fibers for semen induced antihiv vaginal drug delivery. The ortho phthalate esters dbp and dep are lowmolecular weight ralkyl backbone of 3 or less carbon atoms c3 diesters of orthophthalic acid also called phthalic acid, formed from short chain alcohols. Cellulose acetate phthalate, cap withstands itself in acidic media in stomach. Application cap is used as a stabiling agent in the preparation of pseudolatex.
The top countries of suppliers are india, china, from which the percentage of cellulose acetate powder supply is 1%, 97% respectively. Ion transport through surfactant modified cellulose. Hydroxypropyl methylcellulose phthalate inactive ingredient. Hhpc, hydroxypropyl methyl cellulose phthalate hpmcp, hydroxypropyl methyl cellulose acetate succinate hpmcas, microcrystalline cellulose mcc and polyanionic cellulose pac,etc.
Cellulose acetate phthalate as an enteric coating material. This is a chemical reaction in which water is added to the cellulose acetate polymer causing the release of acetic acid molecules. Cellulose acetate is derived from renewable resources such as wood pulp, which differs from most other manmade polymers which are petrochemical derivitives. Cellulose acetate is spun into textile fibres known variously as acetate rayon, acetate, or triacetate. This ester and its salts have been disclosed in patents by malm and waring 5 and have. Cellulose esters have played a vital role in the development of modern drug delivery technology. Nov 14, 2003 cellulose acetate phthalate cap has been used for several decades in the pharmaceutical industry for enteric film coating of oral tablets and capsules. The formation of esters occurs when the non modified. Cellulose acetate phthalate, film coating of tablets, enteric. Cellulose acetate phthalate is a reaction product of phthalic anhydride and a partial acetate ester of cellulose. Cellulose acetate is one of the most important esters of cellulose. Pdf cellulose acetate phthalate cap is a commonly used enteric coating polymer. Cellulose acetate phthalate, a common pharmaceutical. Effect of plasticizers on some physical properties of.
Psfcap blend membranes with blend composition of 955, 9010, 8515 and 8020 wt% of total. Pdf cellulose acetate blends effect of plasticizers on. When appropriately formulated in micronized form, it inactivates various viruses. It can also be molded into solid plastic parts such as tool handles or cast into film for. Coating of oral beclomethasone dipropionate capsules with. From these observations it is concluded that high levels of cellulose acetate phthalate in the diet of rats interfere quantitatively and mechanically with the absorption of food. Cellulose acetate phthalate cap is a hydrophilic polymer which is able to improve the hydrophobicity of prepared membranes by blending with polyethersulfone in the casing solution. Cellulose acetate phthalate is a commonly used tablet coating material employed to produce socalled enteric films, which resist prolonged contact with the strongly. A formulation containing cellulose acetate phthalate for preparing entericcoated granules was developed with the use of granulation and microencapsulation techniques. Cellulose acetate phthalate cap is a commonly used enteric coating polymer.
Cellulose acetate phthalate may play a role as an as antifouling agent. The previous low acetate values arrived at produced speculation on two points. Cab, commonly known as butyrate, is resistant to ultraviolet rays, has a lower moisture absorption than cellulose acetate, and has an extremely highimpact strength. It is tasteless and odorless, or might have a slight odor of acetic acid. Material safety data sheet section 1 cellulose acetate phthalate 1 chemical product and company identification msds name. Cellulose acetate phthalate substance information echa. Abstract the effects of several plasticizers on the following properties of cellulose acetate phthalate films were studied. The effect of concentration and type of plasticizer on the mechanical properties of cellulose acetate butyrate organicinorganic hybrids 143 be used as lower cost, partial replacement for a. Three otc drug and dietary supplement products listed dbp, 64 listed dep, and. It has therefore found a use in the enteric coating field. First that the cellulose acetate might have a limited solubility, in the aceticacid, and second, tat tile spitting out of h20 on the formation of the acetate diluted the solution so tat an early equilibirium was reached. Cellulose acetate hydrogen phthalate not listed as.
Cellulose acetate phthalate, belonging to cellulose esters, is prime among derived natural polymers and is sensitive to biodegradation. Medicines are derived from plants and, many of those that are not, are chemicals synthesized to mimic active principles originally purified from plants and used medicinally cellulose acetate phthalate. The cellulose acetate phthalates have an inherent viscosity of about 0. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed. Cellulose acetate phthalate cellacefate latest price. Characterization of cellulose acetate phthalate cap. Ramsey journal of pharmacology and experimental therapeutics march 1, 1944, 80 3 241249. Synthesis and characterization of a new cellulose acetate. Application of cellulose and cellulose derivatives in. On the other hand, after interaction of mt backing with the eapc nsf, an additive probably a plasticizer, diethyl phthalate, commonly used in the production of cellulose acetate based psts 19.
Enteric coatings of such compositions are more effective than when the ester alone is used. More information about cellulose acetate phthalate in vaccines coming soon. Heparin and lmwh entrapped alginate beads were further surfaceenteric coated with chitosan and cellulose acetate phthalate via carbodiimide functionalities these results established the feasibility of modifying the formulation in order to obtain the desired controlled release of bioactive agent for a convenient ph dependent delivery system 273. Material safety data sheet eastman chemical company. It is a cellulose polymer where about half of the hydroxyls are esterified with acetyls, a quarter are esterified with one or two carboxyls of a phthalic acid, and the remainder are unchanged. Eastman esterifies cellulose to produce cellulose acetate ca, cellulose acetate butyrate cab, and cellulose acetate phthalate cap. Addition of plasticizers improves the water resistance of the ester. Chemical structure of plasticizers diethyl phthalate and triacetin 33 figure 17. The release mechanism for the tablets or tabletted microcapsules. Water dispersible microbicidal cellulose acetate phthalate. Besides, you can learn about the latest development of the cellulose acetate sheet industry and get the cellulose acetate sheet sourcing suggestions from our online industryspecific magazines and trade fairs. Cellulose acetate phthalate european pharmacopoeia ep reference standard. Feb 05, 2020 daicel aimed developing flameretardant celluloid since the companys founding, and succeeded in industrialization of cellulose acetate flakes in 1935.
Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. Drug development and industrial pharmacy, 241 i, 10251041 1998 researchpaper characterization of cellulose acetate phthalate cap pernilla roxin, anders karlsson, satish k. Eastman cellulose esters have unique properties to address mechanical strength and permeability needed for drug delivery applications. Sourcing hot and quality cellulose acetate sheet and keeping up with industry trends are much easier and convenient than you think. High doses of cellulose acetate phthalate in the diet tended to produce a mucilaginous character of the material in the intestinal lumen. Pdf preparation and evaluation of cellulose acetate phthalate. Cellulose acetate, synthetic compound derived from the acetylation of the plant substance cellulose. Properties and applications of cellulose acetate steffen fischer,1 katrin thu. Cellulose acetate phthalate 9004380 c116h116o64 sigma. Store in a cool, dry wellventilated location, away from any area where the fire hazard may be acute. In truth, acetate film and sheets are a specific type of plastic material called cellulose acetate, which is derived from natural sources like wood pulp and cotton. The nsphs and ncs were prepared using the emulsiondi usion technique and then characterized according to encapsulation e ciency ee, size, zetapotential, morphology. Mohan and coworkers, studied the cellulose acetate polysulfone and polyethersulfone blend membranes. Abstractcellulose acetate phthalate cap is a commonly used enteric coating polymer.
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